Articles

RNA levels control phase separation of RNA-binding proteins in cells. Here, the authors show that high RNA concentrations suppress hnRNPA1 phase separation by inducing the formation of nano-sized protein-RNA clusters in the dilute phase, which convert to amyloid fibrils more slowly than condensates.

Mechanochemical polymerisations enable solvent-free conditions, but applying them towards controlled radical polymerisations is a challenge. Here, the authors design methacrylate monomers with varying pendant groups for mechanochemical atom transfer radical polymerisation, and explore how these impact their polymerisation and depolymerisation kinetics.

The study introduces FMOPhore, a computational tool that identifies key binding site residues to improve drug design by guiding efficient fragment growth and lead optimization across diverse protein targets.

Adverse events from chemotherapy are common; however, identifying related symptoms following these events from clinical documentation can be challenging. Here, the authors develop a natural language processing model to extract symptoms from clinical notes.

Coiled animal excreta have fascinated naturalists since Darwin’s observations of earthworm castings, yet the physics are poorly understood. Authors study lugworm feces to provide a mechanical framework for fecal shape and how waste disposal in animals creates distinct buckling regimes.

Flexible electrodes offer higher biocompatibility but remain difficult to locate inside the brain, limiting data interpretation and targeting. Here, the authors demonstrate electrodes with magnetic tags for identification and localization.

Acinetobacter baumannii is an important bacterial pathogen, yet little is known about non-human sources. Here, in a One Health angle, the authors characterize a large set of A. baumannii genomes from different non-human sources revealing large diversity and ARG carriage, which may represent a potential public health concern.

Biomass-based radiative cooling materials face trade-offs between performance, durability, and eco-friendly processes. Here, authors report a high-performance, recyclable cooling biocomposite directly fabricated from wood via an energy-saving method.

Male reproductive aging is poorly understood. Here, the authors show that Sirtuin 7 preserves spermatogenesis by regulating H3K36 acetylation, chromatin accessibility, and DNA repair, protecting germline genome stability during aging and stress.

Infections caused by multi-drug resistant bacteria present a global health challenge, so the identification of bacterial species is essential to avoid the unnecessary use of antibiotics and to minimize the emergence of additional resistance. Here, the authors present a lifetime cross-reactive sensor array that correctly assigned all seven ESKAPEE bacterial species by combining their optical signatures.

Gauthey and colleagues leverage the light beads microscopy method for high-speed whole-brain imaging in behaving Drosophila, revealing fast auditory responses missed by conventional two-photon microscopy.

The manufacture of multispecific antibodies can require complex engineering. Here, the authors develop Fc-FcγR disulfide-linked complexes that can be used for modular delivery of diverse payloads.

How the brain combines sensory information during visual perception remains unclear. Here the authors show that broadband activity in visual cortex encodes synergistic information about images, whereas oscillatory activity encodes more redundant representations.

Conventional Si-based physical unclonable functions (PUFs) are normally limited by limited entropy and lack of reconfigurability, exposing them to machine learning attacks. Here, the authors report optically reconfigurable PUFs based on 2D MoS₂ ring-oscillator arrays, demonstrating machine-learning-attack-resistant image encryption.

The authors report associations of social isolations and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioral phenotypes among UK Biobank participants.

Left hemisphere language dominance emerges across childhood. Whole-brain modelling reveals that asymmetric interhemispheric inhibition is initially masked in early development and progressively unmasked with maturation, driving hemispheric specialization.

Alternative transcription start sites generate transcript diversity but are difficult to detect due to RNA degradation in 5’ scRNA-seq. Here, the authors present scATS, which corrects degradation to quantify TSS usage, improve cell clustering, and identify lung cancer-promoting TSS isoforms.

Liquid–liquid phase separation organizes cellular signaling, but its role in antiviral RNA sensing remains to be further explored. The authors here show that CSDE1 forms condensates that sequester viral RNA and exclude RIG-I to suppress immunity, while targeting CSDE1 condensation suppresses viral replication.

The authors report an artificial plateau neuron with bistable, spike-malleable dynamics that generates programmable rhythmic bursts, enabling a quadruped robot to walk adaptively and energy-efficiently via distributed hardware control without centralized computation.

The neural basis of spatial attention is not fully understood. Here authors show a population of ancient inhibitory brainstem neurons that are essential for accurate and precise selection of the target of spatial attention among distractors, and for shaping competitive stimulus representations in the brain.